Vicodin is a pharmaceutical that is used as a potent pain reliever and antitussive drug. Only sold by prescription in a way that can easily cause addiction. In some countries it is strictly prohibited. So what is Vicodin: a medicine or a potent drug?
Medical Use of Vicodin
Vicodin for sale contains two substances – hydrocodone and paracetamol. The first is a semi-synthetic opioid, a codeine derivative, that is more effective at calming coughs. Second, acetaminophen, and anilide analgesic, is added to the medicine to enhance pain suppression.
Due to the accumulation of paracetamol in the body, the dosage of the substance per day is limited as it can reach toxic concentrations.
Order vicodin online is available in the form of tablets, elixir, and solutions. Used for pain relief after surgery, soothing cough in patients with various diseases of the lungs and upper respiratory tract (including tuberculosis of the lungs and larynx, lung cancer). And also in the absence of positive dynamics from the intake of codeine.
Mechanism Of Action
The pharmacokinetics of the Vicodin drug can be divided into the separate effects of the components:
Hydrocodone is a weak agonist of the kappa and delta-opioid receptors. The main action is directed at m-opioid receptors. When pills are taken, the substance is absorbed from the gastrointestinal tract and 50% binds to blood plasma. The effect begins to manifest itself half an hour after application. Half of the tablet relieves pain for 3-4 hours and the whole for 7-8 hours. In the human body, hydrocodone is metabolized to or hydrocodone and hydromorphone.
Acetaminophen is an inhibitor of the cyclooxygenase enzyme that produces prostaglandins that are responsible for pain. Slowing down the activity of the enzyme reduces pain. The cut-off concentration after ingestion is reached after 10-60 minutes. Paracetamol breaks down in the body within 3 hours. Acetaminophen metabolites are non-toxic, 85% of the tablet taken orally is excreted through the kidneys. Overdose leads to the accumulation of highly reactive compounds, leading to liver damage.
What will happen from the systematic adoption of Vicodin? Regular intake of the drug, which contains components that affect opioid receptors, increases drug tolerance. A person gradually develops physical and mental dependence. Because of this, hydrocodone is classified as a Schedule I pharmacological agent and compared with codeine. .
A sharp refusal after systematic use causes a withdrawal reaction of the body:
- decreased appetite;
- increased activity of mucous membranes (runny nose);
- manifestation of panic attacks;
- the appearance of pain in the abdomen;
- nausea, vomiting;
- violation of thermoregulation.
Violations in the central nervous system (dizziness), abnormalities in the work of the digestive and urinary system, insufficient blood supply, withdrawal symptoms indicate the abuse of Vicodin.
Symptoms of Vicodin Addiction
Symptoms of addiction to the drug Vicodin manifest gradually. Their development is influenced by the dosage of the drug. Increasing the daily dose makes symptoms more severe and may lead to overdose.
The emergence of addiction affects the psychological and physical state of health. A person may develop a number of mental disorders, aggression, constant fatigue, drowsiness, amnesia, a desire to receive a new dose of the drug, and the occurrence of uncontrolled actions.